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KMID : 1137820190400050189
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의공학회지
2019 Volume.40 No. 5 p.189 ~ p.196
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Hippocampal and Ventricular Volumes of Idiopathic Normal-pressure Hydrocephalus and the Cerebrospinal Fluid Tap Test
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Kang Kyung-Hun
Han Jae-Hwan
Yoon Ui-Cheul
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Abstract
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We investigated differences in ventricular and hippocampal volumes between CSF tap test (CSFTT) responders and non-responders in idiopathic normal-pressure hydrocephalus (INPH) patients and compared these parameters in INPH patients with that of age- and gender-matched healthy controls. We also evaluated relationships between ventricular and hippocampal volumes and clinical profiles in INPH patients. We enrolled 48 patients with INPH and 29 healthy controls. Ventricular and hippocampal volumes were measured on MRI, including 3-dimensional volumetric images. INPH patients, when compared to healthy controls, had significantly larger ventricular and smaller hippocampal volumes. No difference in ventricular and hippocampal volumes was found between CSFTT responders and non-responders in INPH patients. And hippocampal volumes showed significant negative correlations with Clinical Dementia Rating Scale scores, INPH grading scale cognitive scores, Timed Up and Go Test scores, and Unified Parkinson’s Disease Rating Scale motor scores in INPH patients. Volumetric assessment of ventricular and hippocampal regions may have no predictive value in differentiating between CSFTT responders and non-responders in INPH patients. Our findings may help us understand the potential pathophysiology of unique symptoms associated with INPH.
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KEYWORD
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Idiopathic normal pressure hydrocephalus, Cerebrospinal fluid tap test, Magnetic resonance imaging, Hippocampus
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